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Claudin-2 (8H11) Mouse mAb

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EM1403

规格：	价钱：
50?L	￥1280.00
100?L	￥1980.00

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Overview

产品名称:	Claudin-2 (8H11) Mouse mAb
反应性:	Human, Rat, Mouse
宿主:	Mouse
稀释比:	WB 1:1,000-2,000?? IHC:1;100-1:200
免疫原:	Synthetic Peptide
贮存条件:	PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
克隆性:	Monoclonal
抗体亚型:	IgG1
浓度:	1mg/mL
实测条带:	25kDa
基因ID:	9075
卵白序列:	P57739
细胞定位:	Cell junction,tight junction,Cell membrane
研究配景:	The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney, where it regulates transepithelial ion (e.g., Na+, Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines , including A549 lung adenocarcinoma cells, where its nuclear distribution was positively associated with enhanced proliferation .

Western blot analysis of 1) Hela Cell Lysate, 2) Mouse Heart Tissue Lysate , 3) Rat Heart Tissue Lysate using Claudin-2 （EM1403）Mouse mAb diluted at 1:2000.
Immunohistochemical analysis of paraffin-embedded Human Kidney Carcinoma Tissue using Claudin-2 （EM1403）Mouse mAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Human Endometrial Carcinoma Tissue using Claudin-2 （EM1403）Mouse mAb diluted at 1:200.

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