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EGFR Mouse mAb

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EM1044

规格：	价钱：
50?L	￥1280.00
100?L	￥1980.00

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Overview

产品名称:	EGFR Mouse mAb
反应性:	Human
又名:	Epidermal Growth Factor Receptor ;ErbB-1; ErbB1; ER1; ERB-B1; MENA; HER1; Erythroblastic Leukemia Viral(v-Erb-B)oncogene Homolog,Avian; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
宿主:	Mouse
稀释比:	WB 1:1,000 IF 1;100-200? IHC 1:200-500
免疫原:	Synthetic Peptide
贮存条件:	PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
克隆性:	Monoclonal
抗体亚型:	IgG1
浓度:	1mg/mL
实测条带:	170kDa
基因ID:	1956
卵白序列:	P00533
细胞定位:	Secreted and Cell membrane. Endoplasmic reticulum membrane
研究配景:	The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascadesβ-Actin is one of six different actin isoforms that have been identified. The actin molecules found in cells of various species and tissues tend to be very similar in their immunological and physical properties. Therefore, Antibodies against β-Actin are useful as loading controls for Western Blotting. However it should be noted that levels of β-Actin may not be stable in certain cells. For example, expression of β-Actin in adipose tissue is very low and therefore β-Actin should not be used as loading control for these tissues.

Western blot analysis of Hela with EGFR mAb diluted at 1:1,000.
IF analysis of Hela with EM1044(Left) and DAPI (Right) diluted at 1:100.
Immunohistochemical analysis of paraffin-embedded Human Lung caricnoma using EGFR （EM1044）Mouse mAb diluted at 1:500.

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