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Overview 文献(91)
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Bioactive Materials
Prophylactic self-assembled nucleic acid hydrogel targeting retinal ganglion cell cuproptosis and microglial neuroinflammation for retinal ischemia-reperfusion injury
日期：2026-02-27
IF：20.3
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ACS Nano
Platelet and Erythrocyte Membranes Coassembled Biomimetic Nanoparticles for Heart Failure Treatment
日期：2024-08-22
IF：15.8
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nature communications
Manganese-engineered Lactobacillus Reuteri with enhanced antitumor and immunomodulatory activities for colorectal cancer prevention and treatment
日期：2025-12-19
IF：15.7
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nature communications
Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis
日期：2025-10-02
IF：15.7
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Small
Cell-Free Extracts from Human Fat Tissue with a Hyaluronan-Based Hydrogel Attenuate Inflammation in a Spinal Cord Injury Model through M2 Microglia/Microphage Polarization
日期：2022-03-25
IF：15.153
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Advanced Science
Engineered Macrophage Membrane-Coated S100A9-siRNA for Ameliorating Myocardial Ischemia-Reperfusion Injury
日期：2024-09-12
IF：14.3
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Advanced Science
Constitutive Androstane Receptor in Macrophages Regulates Toll-Like Receptor 4-Mediated Innate Immune Responses Against Endotoxemic Liver Injury
日期：2025-04-14
IF：14.1
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Theranostics
Injectable SF-platform orchestrates GPX4-targeted ferroptosis-autophagy-immunogenic circuit for overcoming oxidative resistance in triple-negative breast cancer
日期：2025-07-13
IF：13.3
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Journal of Advanced Research
A Rsv@HMnO2-HA nanozyme for AKI therapy via targeting inflammatory storm and activating SIRT1/PGC-1α to restore mitochondrial homeostasis
日期：2026-03-17
IF：13
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small
Redox-Responsive AIEgen Diselenide-Covalent Organic Framework Composites Targeting Hepatic Macrophages for Treatment of Drug-induced Liver Injury
日期：2024-08-14
IF：13
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Biomaterials
Dual-targeting nuclear and mitochondrial DNA damage drives immunogenic activation via PANoptosis for synergistic magneto-thermodynamic-chemotherapy
日期：2025-12-15
IF：12.9
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BIOMATERIALS
Modification of MSCs with aHSCs-Targeting Peptide pPB for Enhanced Therapeutic Efficacy in Liver Fibrosis
日期：2025-03-28
IF：12.8
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Small
Homocysteine-Responsive Covalent Organic Frameworks as Signaling Scaffolds: Modulating Transsulfuration for Depression Treatment
日期：2025-04-17
IF：12.1
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Cell Reports Medicine
Tailoring an intravenously injectable oncolytic virus for augmenting radiotherapy
日期：2025-04-14
IF：11.7
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Clinical and Translational Medicine
Inhibition of TGFβ1 activation prevents radiation-induced lung fibrosis
日期：2024-01-18
IF：10.6
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International Journal of Biological Sciences
DHCR24 Deficiency Drives Age-Related Meibomian Gland Dysfunction by Regulating Lipid Metabolic Imbalance and Cytosolic mtDNA-Induced cGAS-STING Activation
日期：2026-03-26
IF：10
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Advanced Healthcare Materials
Glucose-Responsive Zn(II)-Porphyrin COF Adhesive Hydrogels With Dual-Active Sites and GOX-Like Activity for Accelerated Wound Healing
日期：2025-01-02
IF：10
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Environment International
Synergistic disruption of blood-brain barrier and neuroimmune homeostasis by sleep-related environmental pollutants drives sleep disorders: an integrated computational and experimental study
日期：2026-01-20
IF：9.7
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Burns & Trauma
Hybrid Nanovesicles Promote Diabetic Wound Healing via Dual-Targeted Multimodal Therapy
日期：2026-01-13
IF：9.6
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Advanced Healthcare Materials
Incorporating Stem Cell-Derived Small Extracellular Vesicles into a Multifunctional OHAMA-EPL Hydrogel Spray for Rapid Healing of Infected Skin Wounds
日期：2025-04-14
IF：9.6
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Phytomedicine
Theaflavin-3,3′-digallate stabilizes vulnerable plaques by reprogramming metabolic homeostasis in neovascularization via HK2/TIGAR
日期：2025-06-26
IF：8.3
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ACS Applied Materials & Interfaces
Inhibition of Transmural Inflammation in Crohn’s Disease by Orally Administered Tumor Necrosis Factor-Alpha Deoxyribozymes-Loaded Pyroptosis Nanoinhibitors
日期：2024-07-25
IF：8.3
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Free Radical Biology and Medicine
Forchlorfenuron exposure induces cardiotoxicity via NF-κB/NLRP3-mediated inflammasome activation independent of Septin2 inhibition
日期：2026-01-16
IF：8.2
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International Journal of Biological Sciences
NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease
日期：2024-03-25
IF：8.2
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Int J Biol Sci
Nintedanib Mitigates Radiation-Induced Pulmonary Fibrosis by Suppressing Epithelial Cell Inflammatory Response and Inhibiting Fibroblast-to-Myofibroblast Transition
日期：2024-06-11
IF：8.2
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International Journal of Biological Macromolecules
Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule
日期：2023-12-25
IF：8.2
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International Journal of Biological Macromolecules
Gut microbiota-derived 5-hydroxyindoleacetic acid from pumpkin polysaccharides supplementation alleviates colitis via MAPKs-PPARγ/NF-κB inhibition
日期：2024-04-30
IF：7.7
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Biomedicine & Pharmacotherapy
Shen Qi Wan ameliorates nephritis in chronic kidney disease via AQP1 and DEFB1 regulation
日期：2023-12-14
IF：7.5
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INFLAMMATION RESEARCH
ACY-1215 ameliorates experimental colitis by inhibiting dendritic cell maturation and Th1/Th17 responses
日期：2026-06-04
IF：6.5
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PHYTOTHERAPY RESEARCH
Isoferulic Acid Mitigates Acute Lung Injury Induced by Sepsis Through the Inhibition of JAK2
日期：2025-06-09
IF：6.3
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npj Science of Food
Formononetin protects against sepsis-induced lung injury by directly inhibiting receptor for advanced glycation end products signaling pathway
日期：2024-10-15
IF：6.3
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Frontiers in Molecular Neuroscience
Netrin-1 Ameliorates Postoperative Delirium-Like Behavior in Aged Mice by Suppressing Neuroinflammation and Restoring Impaired Blood-Brain Barrier Permeability
日期：2022-01-14
IF：6.261
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INDUSTRIAL CROPS AND PRODUCTS
Rosa roxburghii Tratt juice attenuates cisplatin-induced acute kidney injury by alleviating inflammatory response partially related to gut microbiota metabolism
日期：2025-12-01
IF：6.2
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Cell & Bioscience
Trim7 aggravates ischemic stroke–associated ferroptosis by promoting ubiquitin-mediated degradation of HSPA5
日期：2025-09-08
IF：6.2
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ANTIOXIDANTS & REDOX SIGNALING
Activation of Mitophagy by Kinetin Mitigates Coal–Silica Mixed Dust-Induced Pulmonary Fibrosis via Modulating Macrophage Mitochondrial Function in Mice
日期：2026-01-12
IF：6.1
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Food & Function
Egg white-derived peptides reduced blood glucose in high-fat-diet and low-dose streptozotocin-induced type 2 diabetic mice via regulating the hepatic gluconeogenic signaling and metabolic profile
日期：2024-06-07
IF：6.1
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Biochemical Pharmacology
Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis
日期：2022-11-23
IF：6.1
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Frontiers in Cellular and Infection Microbiology
New insights of necroptosis and immune infiltration in sepsis-induced myocardial dysfunction from bioinformatics analysis through RNA-seq in mice
日期：2022-12-21
IF：6.073
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Frontiers in Pharmacology
Protective Effects and Mechanisms of Polyethylene Glycol Loxenatide Against Hyperglycemia and Liver Injury in db/db diabetic Mice
日期：2021-12-06
IF：5.988
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Frontiers in Immunology
Laptm4a mediates renal ischemia-reperfusion injury by regulating the UNC5B-AKT/mTOR signaling pathway
日期：2026-04-14
IF：5.9
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Journal of Molecular Cell Biology
ITIH5 Drives Adipocyte Differentiation and Obesity-Associated Metabolic Dysregulation via PI3K/AKT Signaling Activation
日期：2026-05-08
IF：5.9
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Experimental Neurology
Exosomal miR-23b-3p from bone mesenchymal stem cells alleviates experimental autoimmune encephalomyelitis by inhibiting microglial pyroptosis
日期：2023-05-01
IF：5.62
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Biochemical Pharmacology
Artesunate reduces oxidative stress and inflammation in NAFLD by activating the Nrf2 pathway
日期：2026-01-26
IF：5.6
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Biochemical Pharmacology
Calcitriol protects against diabetic kidney disease by alleviating ferroptosis in renal tubular epithelial cells via JUN/ATF3 pathway
日期：2026-05-31
IF：5.6
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Biochemical Pharmacology
Calcitriol protects against diabetic kidney disease by alleviating ferroptosis in renal tubular epithelial cells via JUN/ATF3 pathway
日期：2026-05-31
IF：5.6
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Biomaterials Advances
Mechanism of selenium-doped black phosphorus nanosheets wrapped with biomimetic tumor cell membrane for prostate cancer immunotherapy
日期：2025-05-16
IF：5.5
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Organic Chemistry Frontiers
Pseudeurglobosins A–F, six rearranged [11]-chaetoglobosins with immunosuppressive activities from Pseudeurotium bakeri P1-1-1
日期：2021-11-09
IF：5.456
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Journal of Ethnopharmacology
Jianpi Antai formula prevents miscarriage by repressing M1 polarization of decidual macrophages through ubiquitination of NLRP3 mediated by MARCH7
日期：2024-01-18
IF：5.4
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CNS Neuroscience & Therapeutics
The Administration of Circulating Extracellular Vesicles Modified by Anesthesia and Surgery Induces Delirium-Like Behaviors in Aged Mice
日期：2025-06-19
IF：5
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International Immunopharmacology
TRIM7 negatively regulates CMPK2 suppressing inflammation and apoptosis in renal ischemia-reperfusion injury
日期：2026-02-05
IF：4.7
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iScience
Behenic acid alleviates inflammation and insulin resistance in gestational diabetes mellitus by regulating TLR4/NF-κB signaling pathway
日期：2024-10-18
IF：4.6
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Inflammation
Puerarin Ameliorates Sarcopenia in Aged Mice via Modulation of Inflammation and Oxidative Stress: Insights from Proteomics and Transcriptomics
日期：2025-03-24
IF：4.5
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Frontiers in Pharmacology
Xanthohumol ameliorates diabetic kidney disease through suppression of renal fibrosis by regulating SNHG10/miR-378b
日期：2025-05-27
IF：4.4
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Frontiers in Pharmacology
Thonningianin A ameliorates acetaminophen-induced liver injury by activating GPX4 and modulating endoplasmic reticulum stress
日期：2025-03-20
IF：4.4
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
High-dose vitamin C attenuates radiation-induced pulmonary fibrosis by targeting S100A8 and S100A9
日期：2024-07-10
IF：4.2
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Virologica Sinica
Isolation and identification of a newly discovered broad-spectrum Acinetobacter baumannii phage and therapeutic validation against pan-resistant Acinetobacter baumannii
日期：2025-06-19
IF：4
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International Immunopharmacology
Extracellular vesicles containing miR-181a-5p as a novel therapy for experimental autoimmune encephalomyelitis-induced demyelination
日期：2024-06-30
IF：4
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FOOD AND CHEMICAL TOXICOLOGY
Inhibiting fatty acid-binding protein 4 reverses inflammation and apoptosis in wasp sting-induced acute kidney injury
日期：2025-03-06
IF：3.9
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Toxicology and Applied Pharmacology
Levocabastine ameliorates cyclophosphamide-induced cardiotoxicity in Swiss albino mice: Targeting TLR4/NF-κB/NLRP3 signaling pathway
日期：2024-01-23
IF：3.8
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AMB Express
Cucurbitacin B alleviates DSS-induced ulcerative colitis by improving gut microbiota disorder in C57BL/6 mice
日期：2025-07-16
IF：3.7
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The American Journal of Pathology
E3 Ubiquitin Ligase TRIM7 Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting NLRP3 Inflammasome Activation
日期：2025-01-24
IF：3.6
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JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Poricoic acid A induces mitophagy to ameliorate podocyte injury in diabetic kidney disease via downregulating FUNDC1
日期：2023-09-14
IF：3.6
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Food Science & Nutrition
Puerarin Delays the Progression of Muscle Atrophy in Mice With Dexamethasone-Induced Sarcopenia Through Inhibiting the TNF-α/NF-κB Pathway
日期：2025-05-18
IF：3.5
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Animal Models and Experimental Medicine
Scalp electroacupuncture targeting trigeminal nerve activation alleviates post-traumatic stress disorder–induced depression and neuroinflammation in mice
日期：2026-03-15
IF：3.4
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BMC Infectious Diseases
Integrated bioinformatics and experiment validation reveal cuproptosis-related biomarkers and therapeutic targets in sepsis-induced myocardial dysfunction
日期：2025-03-31
IF：3.4
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Journal of Physiology and Biochemistry
Caveolin-1 deficiency alleviates palmitate-induced intracellular lipid accumulation and inflammation in pancreatic β cells
日期：2023-10-31
IF：3.4
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RESPIRATORY RESEARCH
HDAC6 inhibition reprograms endothelial and macrophage responses to protect the lung in endotoxemia
日期：2026-05-03
IF：3.4
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Journal of Natural Products
Asperustins A–J: Austocystins with Immunosuppressive and Cytotoxic Activities from Aspergillus ustus NRRL 5856
日期：2024-03-05
IF：3.3
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Diabetes, Metabolic Syndrome and Obesity
Jiangtang Decoction Ameliorates Diabetic Kidney Disease Through the Modulation of the Gut Microbiota
日期：2023-11-07
IF：3.3
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3 Biotech
Hepatoprotective role of verbenone against cyclophosphamide-induced oxidative stress, inflammation, apoptosis, and fibrosis in Swiss albino mice: insights into the involvement of NF-κB, caspase-3, and TGF-β signaling pathways
日期：2025-08-23
IF：2.9
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Infection and Drug Resistance
Validation of Senescence of the Role of ATM/P53 Pathway in Myocardial Senescence in Mice with Sepsis
日期：2025-04-18
IF：2.9
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EUROPEAN JOURNAL OF MEDICAL RESEARCH
The role of m6A methylation genes in predicting poor prognosis in sepsis: identifying key biomarkers and therapeutic targets
日期：2024-12-19
IF：2.8
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Fundamental & Clinical Pharmacology
Exogenous fetuin-A protects against sepsis-induced myocardial injury by inhibiting oxidative stress and inflammation in mice
日期：2023-01-16
IF：2.747
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Immunity, Inflammation and Disease
RANKL Attenuates Sepsis-Associated Acute Lung Injury Through the OPG/RANKL/RANK/TLR4 Pathway
日期：2026-03-06
IF：2.7
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International Journal of Food Science
Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Aegle marmelos Juice
日期：2025-04-02
IF：2.7
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Evidence-Based Complementary and Alternative Medicine
Dl-3-n-Butylphthalide (NBP) Mitigates Muscular Injury Induced by Limb Ischemia/Reperfusion in Mice through the HMGB1/TLR4/NF-κB Pathway
日期：2022-09-26
IF：2.65
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Evidence-based Complementary and Alternative Medicine
Sulforaphane Ameliorates Limb Ischemia/Reperfusion-Induced Muscular Injury in Mice by Inhibiting Pyroptosis and Autophagy via the Nrf2-ARE Pathway
日期：2022-05-11
IF：2.629
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Evidence-based Complementary and Alternative Medicine
Scorpion Venom Polypeptide Inhibits Pulmonary Epithelial-mesenchymal Transition in Systemic Sclerosis-interstitial Lung Disease Model Mice by Intervening TGF-β1/Smad Signaling Pathway
日期：2022-04-13
IF：2.629
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MOLECULAR BIOLOGY REPORTS
Wnt1 oversees microglial activation by the Wnt/LRP5/6 receptor signaling pathway during lipopolysaccharide-mediated toxicity
日期：2025-03-01
IF：2.6
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Molecular Biology Reports
Poricoic acid a ameliorates high glucose-induced podocyte injury by regulating the AMPKα/FUNDC1 pathway
日期：2024-09-21
IF：2.6
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PeerJ
Behavioral and biological alterations following transplantation of ASD-associated gut microbiota in mice
日期：2026-03-24
IF：2.4
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Food Biotechnology
Immunomodulatory effects of Bacillus subtilis-fermented soybean extract in mice
日期：2022-11-23
IF：2.297
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BMC Nephrology
Role of OPG/RANKL/RANK/TLR4 signaling pathway in sepsis-associated acute kidney injury
日期：2024-06-23
IF：2.2
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EUROPEAN JOURNAL OF HISTOCHEMISTRY
Cryptotanshinone alleviates DSS-induced colitis in mouse by regulating the balance of Treg/Th17 cells and M1 macrophage activation
日期：2026-02-24
IF：2.1
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EUROPEAN JOURNAL OF HISTOCHEMISTRY
Cryptotanshinone alleviates DSS-induced colitis in mouse by regulating the balance of Treg/Th17 cells and M1 macrophage activation Authors
日期：2026-02-19
IF：2.1
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Journal of Clinical Pharmacy and Therapeutics
Effects of Daphnetin on Experimental Acute Pancreatitis-Associated Acute Lung Injury in Mice
日期：2023-08-25
IF：2
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EUROPEAN JOURNAL OF HISTOCHEMISTRY
Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/mir-140-3p/TLR4 axis
日期：2023-07-26
IF：2
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EUROPEAN JOURNAL OF HISTOCHEMISTRY
Dexmedetomidine attenuates neuroinflammation and microglia activation in LPs-stimulated bV2 microglia cells through targeting circ-shank3/mir-140-3p/tLr4 axis
日期：2023-07-26
IF：2
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European Journal of Histochemistry
Combination of tolvaptan and valsartan improves cardiac and renal functions in doxorubicin-induced heart failure in mice
日期：2022-11-11
IF：1.966
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Journal of Taibah University Medical Sciences
Inflammatory effects of commercial and natural mosquito repellents on respiratory system in male and female mice
日期：2026-04-09
IF：1.9
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Open Veterinary Journal
The effect of topical and oral combination of ethanolic extract of Graptophyllum pictum leaf on the inflammation level of rectoanal tissue in hemorrhoid-induced rat
日期：2026-03-30
IF：1
标准曲线
| Concentration (pg/mL) | OD | Corrected OD |
|---|---|---|
| 500.00 | 1.964 | 1.851 |
| 250.00 | 1.616 | 1.503 |
| 125.00 | 1.223 | 1.110 |
| 62.50 | 0.728 | 0.615 |
| 31.25 | 0.529 | 0.416 |
| 15.63 | 0.327 | 0.214 |
| 7.82 | 0.217 | 0.104 |
| 0.00 | 0.113 | 0.000 |
细密度
板内细密度（测定内的细密度）：CV%<8%
三个已知浓度的样品划分在1个酶标板上测试20次，，以评估剖析板内细密度。。。
板间细密度（测定板间间细密度）：CV%<10%
三个已知浓度的样品划分在3个差别的酶标板上测试40次，，以评估剖析板间的细密度。。。
接纳率
划分往差别样本中添加已知浓度的小鼠 IL6，，
做接纳率实验，，得出接纳率规模清静均接纳率
| 样本类型 | 接纳率规模 | 平均接纳率 |
|---|---|---|
| 血清(n=5) | 80-97% | 88% |
| EDTA 血浆(n=5) | 88-99% | 93% |
| Heparin 血浆(n=5) | 82-95% | 88% |
线性
将添加有小鼠 IL6的样天职别稀释2倍，，4倍，，8倍，，16倍做接纳实验，，得出接纳率规模
| 样本类型 | 1:2 | 1:4 | 1:8 | 1:16 |
|---|---|---|---|---|
| 血清(n=5) | 82-93% | 95-104% | 82-96% | 85-98% |
| EDTA 血浆(n=5) | 88-102% | 87-102% | 85-96% | 87-101% |
| Heparin 血浆(n=5) | 87-94% | 85-96% | 89-100% | 85-96% |
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