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Overview 文献(37)
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Advanced Science
Engineered Macrophage Membrane-Coated S100A9-siRNA for Ameliorating Myocardial Ischemia-Reperfusion Injury
日期：2024-09-12
IF：14.3
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Advanced Science
Mussel-Derived and Bioclickable Peptide Mimic for Enhanced Interfacial Osseointegration via Synergistic Immunomodulation and Vascularized Bone Regeneration
日期：2024-06-23
IF：14.3
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BIOMATERIALS
Modification of MSCs with aHSCs-Targeting Peptide pPB for Enhanced Therapeutic Efficacy in Liver Fibrosis
日期：2025-03-28
IF：12.8
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JOURNAL OF NANOBIOTECHNOLOGY
Exosomal miR-499a-5p from human umbilical cord mesenchymal stem cells attenuates liver fibrosis via targeting ETS1/GPX4-mediated ferroptosis in hepatic stellate cells
日期：2025-03-19
IF：10.6
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Clinical and Translational Medicine
Inhibition of TGFβ1 activation prevents radiation-induced lung fibrosis
日期：2024-01-18
IF：10.6
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Materials Today Bio
Ruthenium coordinated nanohybrids modulate tumor microenvironment and potentiate amplified phototherapy augmented immunotherapy of hypoxic tumor
日期：2025-11-17
IF：10.2
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Burns & Trauma
Hybrid Nanovesicles Promote Diabetic Wound Healing via Dual-Targeted Multimodal Therapy
日期：2026-01-13
IF：9.6
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Advanced Healthcare Materials
Incorporating Stem Cell-Derived Small Extracellular Vesicles into a Multifunctional OHAMA-EPL Hydrogel Spray for Rapid Healing of Infected Skin Wounds
日期：2025-04-14
IF：9.6
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Phytomedicine
Urolithin B promotes the functional recovery of spinal cord injury by alleviating neuroinflammation via the inhibition of NLRP3 signaling pathway
日期：2025-09-24
IF：8.3
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ACS Applied Materials & Interfaces
Inhibition of Transmural Inflammation in Crohn’s Disease by Orally Administered Tumor Necrosis Factor-Alpha Deoxyribozymes-Loaded Pyroptosis Nanoinhibitors
日期：2024-07-25
IF：8.3
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International Journal of Biological Macromolecules
MG53/GMs/HA-Dex neural scaffold promotes the functional recovery of spinal cord injury by alleviating neuroinflammation
日期：2024-04-04
IF：8.2
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International Journal of Biological Macromolecules
Gut microbiota-derived 5-hydroxyindoleacetic acid from pumpkin polysaccharides supplementation alleviates colitis via MAPKs-PPARγ/NF-κB inhibition
日期：2024-04-30
IF：7.7
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Frontiers in Molecular Neuroscience
Netrin-1 Ameliorates Postoperative Delirium-Like Behavior in Aged Mice by Suppressing Neuroinflammation and Restoring Impaired Blood-Brain Barrier Permeability
日期：2022-01-14
IF：6.261
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Frontiers in Microbiology
Heat-killed Lactobacillus reuteri PSC102 Ameliorates Impaired Immunity in Cyclophosphamide-Induced Immunosuppressed Mice
日期：2022-08-12
IF：6.064
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Frontiers in Pharmacology
Protective Effects and Mechanisms of Polyethylene Glycol Loxenatide Against Hyperglycemia and Liver Injury in db/db diabetic Mice
日期：2021-12-06
IF：5.988
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International Immunopharmacology
Deletion of Insulin-like growth factor II mRNA-binding protein 3 participates in the pathogenesis of recurrent spontaneous abortion by inhibiting IL-10 secretion and inducing M1 polarization
日期：2023-01-01
IF：5.714
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Indole-3-Propionic Acid Attenuates Neuroinflammation and Cognitive Deficits by Inhibiting the RAGE-JAK2-STAT3 Signaling Pathway
日期：2025-02-24
IF：5.7
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Journal of Agricultural and Food Chemistry
Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway
日期：2024-08-03
IF：5.7
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Biochemical Pharmacology
Calcitriol protects against diabetic kidney disease by alleviating ferroptosis in renal tubular epithelial cells via JUN/ATF3 pathway
日期：2026-05-31
IF：5.6
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Biochemical Pharmacology
Calcitriol protects against diabetic kidney disease by alleviating ferroptosis in renal tubular epithelial cells via JUN/ATF3 pathway
日期：2026-05-31
IF：5.6
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Biomaterials Advances
Mechanism of selenium-doped black phosphorus nanosheets wrapped with biomimetic tumor cell membrane for prostate cancer immunotherapy
日期：2025-05-16
IF：5.5
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Organic Chemistry Frontiers
Pseudeurglobosins A–F, six rearranged [11]-chaetoglobosins with immunosuppressive activities from Pseudeurotium bakeri P1-1-1
日期：2021-11-09
IF：5.456
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Journal of Ethnopharmacology
Jianpi Antai formula prevents miscarriage by repressing M1 polarization of decidual macrophages through ubiquitination of NLRP3 mediated by MARCH7
日期：2024-01-18
IF：5.4
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Food&Function
Gut microbiota modulation and effects of a diet enriched in apple pomace on inflammation in a DSS-induced colitis mouse model
日期：2024-02-07
IF：5.2
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CNS Neuroscience & Therapeutics
The Circadian Clock Gene Bmal1 Regulates Microglial Pyroptosis After Spinal Cord Injury via NF-κB/MMP9
日期：2024-12-08
IF：4.8
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Investigative Ophthalmology & Visual Science
Subconjunctival Injection of Regulatory T Cells Potentiates Corneal Healing Via Orchestrating Inflammation and Tissue Repair After Acute Alkali Burn
日期：2020-11-30
IF：4.799
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Inflammation
Puerarin Ameliorates Sarcopenia in Aged Mice via Modulation of Inflammation and Oxidative Stress: Insights from Proteomics and Transcriptomics
日期：2025-03-24
IF：4.5
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International Immunopharmacology
Extracellular vesicles containing miR-181a-5p as a novel therapy for experimental autoimmune encephalomyelitis-induced demyelination
日期：2024-06-30
IF：4
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International Journal of Hyperthermia
Microwave ablation combined with anti-PD-1 therapy enhances systemic antitumor immunity in a multitumor murine model of Hepa1-6
日期：2022-02-06
IF：3.914
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BIOSCIENCE REPORTS
Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway
日期：2019-07-19
IF：3.84
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Food Science & Nutrition
Puerarin Delays the Progression of Muscle Atrophy in Mice With Dexamethasone-Induced Sarcopenia Through Inhibiting the TNF-α/NF-κB Pathway
日期：2025-05-18
IF：3.5
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3 Biotech
Hepatoprotective role of verbenone against cyclophosphamide-induced oxidative stress, inflammation, apoptosis, and fibrosis in Swiss albino mice: insights into the involvement of NF-κB, caspase-3, and TGF-β signaling pathways
日期：2025-08-23
IF：2.9
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NANOTECHNOLOGY
Construction of recombinant Omp25 or EipB protein loaded PLGA nanovaccines for Brucellosis protection
日期：2024-07-12
IF：2.9
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MOLECULAR BIOLOGY REPORTS
Wnt1 oversees microglial activation by the Wnt/LRP5/6 receptor signaling pathway during lipopolysaccharide-mediated toxicity
日期：2025-03-01
IF：2.6
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PeerJ
Behavioral and biological alterations following transplantation of ASD-associated gut microbiota in mice
日期：2026-03-24
IF：2.4
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BRAZILIAN JOURNAL OF MICROBIOLOGY
Genotypic and phenotypic characterization of Pseudomonas aeruginosa PAV112: a virulent clinical strain causing severe pneumonia and lethal sepsis in a murine infection model
日期：2026-01-16
IF：1.9
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International Journal of Ophthalmology
Ragweed pollen induces allergic conjunctivitis immune tolerance in mice via regulation of the NF-κB signal pathway
日期：2021-07-18
IF：1.779
标准曲线
| Concentration (pg/mL) | OD | Corrected OD |
|---|---|---|
| 500.00 | 2.126 | 2.040 |
| 250.00 | 1.673 | 1.587 |
| 125.00 | 1.128 | 1.042 |
| 62.50 | 0.901 | 0.815 |
| 31.25 | 0.614 | 0.528 |
| 15.63 | 0.403 | 0.317 |
| 7.82 | 0.256 | 0.170 |
| 0.00 | 0.086 | 0.000 |
细密度
板内细密度（测定内的细密度）：CV%<8%
三个已知浓度的样品划分在1个酶标板上测试20次， ，，以评估剖析板内细密度。。。
板间细密度（测定板间间细密度）：CV%<10%
三个已知浓度的样品划分在3个差别的酶标板上测试40次， ，，以评估剖析板间的细密度。。。
接纳率
划分往差别样本中添加已知浓度的小鼠 IL10， ，，
做接纳率实验， ，，得出接纳率规模清静均接纳率
| 样本类型 | 接纳率规模 | 平均接纳率 |
|---|---|---|
| 血清(n=5) | 86-97% | 92% |
| EDTA 血浆(n=5) | 84-103% | 96% |
| Heparin 血浆(n=5) | 82-96% | 87% |
线性
将添加有小鼠 IL10的样天职别稀释2倍， ，，4倍， ，，8倍， ，，16倍做接纳实验， ，，得出接纳率规模
| 样本类型 | 1:2 | 1:4 | 1:8 | 1:16 |
|---|---|---|---|---|
| 血清(n=5) | 86-93% | 93-101% | 85-98% | 90-101% |
| EDTA 血浆(n=5) | 91-99% | 83-97% | 87-105% | 87-99% |
| Heparin 血浆(n=5) | 85-90% | 83-96% | 95-102% | 88-95% |
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